首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   182篇
  免费   13篇
  国内免费   9篇
  2019年   1篇
  2018年   1篇
  2017年   1篇
  2015年   12篇
  2014年   9篇
  2013年   10篇
  2012年   7篇
  2011年   15篇
  2010年   8篇
  2009年   11篇
  2008年   6篇
  2007年   9篇
  2006年   15篇
  2005年   6篇
  2004年   6篇
  2003年   6篇
  2002年   5篇
  2001年   6篇
  2000年   5篇
  1999年   4篇
  1998年   7篇
  1997年   6篇
  1996年   5篇
  1995年   3篇
  1994年   6篇
  1993年   2篇
  1992年   3篇
  1991年   1篇
  1989年   1篇
  1988年   1篇
  1987年   2篇
  1986年   4篇
  1985年   3篇
  1984年   2篇
  1983年   2篇
  1982年   2篇
  1981年   2篇
  1980年   2篇
  1978年   1篇
  1977年   3篇
  1955年   1篇
  1954年   2篇
排序方式: 共有204条查询结果,搜索用时 15 毫秒
201.
202.
The structure-function relationship of eight structurally very similarLathyrus lectins, which are two-chain lectins from theVicieae tribe, has been studied. Hemagglutination activity, inhibition of hemagglutination, glycoprotein reactivity and mitogenic activity were determined for each of the lectins. Despite the close structural resemblance, marked differences in the carbohydrate binding activity of theLathyrus lectins were recorded. These functional differences were related to small conformational changes due to minor differences in amino acid sequence of eachLathyrus lectin.  相似文献   
203.
Recombinant DNA clones have been isolated that contain 80 kb of the beta-globin complex from the deer mouse, Peromyscus maniculatus. Comparisons of this complex with that from the laboratory mouse, Mus domesticus (with an order 5'-Hbby, Hbb-bhO, Hbb-bhl, Hbb-bh2, Hbb-bh3, Hbb-bl, Hbb-b2 3') highlight organizational trends in the beta-globin complex since the two species diverged. Unlike other mammals studied thus far, the deer mouse possesses three adult genes. Partial sequence analysis indicates that each of the three adult genes is intact and hence may be functional. Hybridization of one of the two Mus pseudogenes, Hbb-bh3, to genomic blots from Peromyscus reveals that it has a homologous counterpart in Peromyscus. Homologous genes to the two gamma-like Mus genes, Hbb-bhO and Hbb-bhl, are also found in Peromyscus. The strong hybridization between the Hbb-bhl genes and significant nucleotide similarity between the Hbb-bhO genes suggest that both pairs are important for the ontogeny of these mice although no known product has been identified for the Hbb-bhO genes. The presence of Hbb-bhO and Hbb-bhl in Peromyscus suggests that the duplication that created this related gene set occurred before the two lineages diverged. A single gene for Hbb-y has been isolated from Peromyscus. The adult region in Peromyscus has undergone significant divergence from the same region in Mus, having three rather than two adult genes, the acquisition of at least 15 kb of extra DNA relative to Mus, and possibly the loss of the Hbb-bh2 pseudogene. The nonadult region of the complex, in contrast, contains the same set of genes apparently distributed over the same amount of DNA as in the Mus beta- globin complex. This observation suggests that the embryonic region of the complex is more evolutionarily stable than the adult region.   相似文献   
204.
The mitogenic properties of ten phylogenetically related Lathyrus lectins have been studied. Despite a close structural resemblance and similar carbohydrate specificities, the lectins exhibited significant differences in their ability to induce cell proliferation of human lymphocytes. The differences in optimal dose were in the range 10-30 times. L. ochrus (whole lectin) also had an ability to induce cellular growth 3-10 times better than that of the isolated isolectins, L. ochrus I and II, illustrating the complexity behind the structure-function relation of lectin mitogens.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号